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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Penetration of topically applied tacrolimus into the aqueous humor in Behçet's disease
F Nilüfer Yalçindağ1, Figen Batioğlu, Ozden Ozdemir
1Ophthalmology Department, Ankara University Faculty of Medicine, Esat Caddes i 74/3 Küçükesat, Ankara, 06660, Turkey. yalcinda@medicine.ankara.edu.tr
Abstract:
We investigated the concentration of tacrolimus in aqueous humor, and serum of patients with ocular Behçet's disease after topical application in 11 patients. All received 1 drop of isotonic tacrolimus solution 0.3% every 6 hours for 3 days. The mean tacrolimus concentration in the aqueous and serum, as measured by microparticle enzyme immunoassay, were 12.49 and 0.76 ng/mL, respectively. Tacrolimus may be a promising treatment modality in anterior uveitis in Behçet's disease by topical application.
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