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Chronic inflammatory bowel disease in children and adolescents in Sweden

H Hildebrand, B Fredrikzon, L Holmquist

    Journal of Pediatric Gastroenterology and Nutrition
    |October 1, 1991
    PubMed

    Insights

    This Swedish study established the incidence and prevalence of pediatric inflammatory bowel disease (IBD) in children under 16. It found IBD affected approximately 18 per 100,000 children, with ulcerative colitis being most common.

    Area of Science:

    • Pediatric Gastroenterology
    • Epidemiology
    • Chronic Disease Research

    Background:

    • Inflammatory bowel disease (IBD) encompasses chronic conditions like ulcerative colitis (UC) and Crohn's disease (CD).
    • Understanding the pediatric incidence and prevalence of IBD is crucial for public health and resource allocation.

    Purpose of the Study:

    • To prospectively determine the incidence and prevalence of pediatric inflammatory bowel disease (IBD) in Sweden.
    • To classify IBD subtypes, including ulcerative colitis (UC), Crohn's disease (CD), probable Crohn's disease (PCD), and indeterminate colitis (IC).

    Main Methods:

    • A prospective study conducted in Sweden during 1984-1985.
    • Inclusion of 1.51 million children under 16 years, representing 93% of the Swedish pediatric population.
    • Classification of IBD based on histopathologic, endoscopic, and radiologic criteria.

    Main Results:

    • The incidence of IBD was 4.5-5.0 per 100,000 children.
    • The prevalence of IBD ranged from 17.6 to 18.2 per 100,000 children.
    • Mean prevalence: UC (7.5/100,000), CD + PCD (6.2/100,000), and IC (4.2/100,000), with IC comprising 23% of IBD cases.

    Conclusions:

    • This study provides foundational data on the epidemiology of pediatric IBD in a defined population.
    • Ulcerative colitis and indeterminate colitis were significant contributors to the overall prevalence of pediatric IBD.
    • The findings highlight the importance of standardized diagnostic criteria for accurate IBD classification in children.

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