Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transdermal-controlled administration of oxycodone.

J H Tien1

  • 1Medical Laboratories, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Journal of Pharmaceutical Sciences
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pituitary network connectivity as a mechanism for the luteinising hormone surge.

Journal of neuroendocrinology·2010
Same author

Drug utilization pattern of Chinese herbal medicines in a general hospital in Taiwan.

Pharmacoepidemiology and drug safety·2005
Same author

Rational pharmacotherapy in the diabetic hypertension: analysis-prescribing patterns in a general hospital in Taiwan.

Journal of clinical pharmacy and therapeutics·2004
Same journal

Enhanced zika virus suppression by coupling ribavirin with biodegradable drug delivery.

Journal of pharmaceutical sciences·2026
Same journal

Immune tolerance platforms to mitigate unwanted immune responses.

Journal of pharmaceutical sciences·2026
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
See all related articles

Oxycodone permeability through mouse skin is significantly higher for its non-ionized form. Silicone elastomer formulations show release rates proportional to drug loading, impacting skin permeation.

Area of Science:

  • Pharmacokinetics and Drug Delivery
  • Dermal Permeation Studies
  • Materials Science

Background:

  • Oxycodone, a weak base analgesic, exhibits pH-dependent solubility and skin permeability.
  • Understanding drug behavior in transdermal systems is crucial for effective drug delivery.

Purpose of the Study:

  • To investigate the permeability of hairless mouse skin to oxycodone.
  • To evaluate the impact of pH on oxycodone solubility and skin permeation.
  • To assess the release and skin permeation characteristics of oxycodone incorporated in a silicone elastomer.

Main Methods:

  • In vitro skin permeation studies using hairless mouse skin.
  • Solubility and permeation rate measurements at varying pH.
  • Formulation of oxycodone in silicone elastomer with different drug loadings.

Related Experiment Videos

  • Analysis of release kinetics using Higuchi's equation.

    • Main Results:

    • Permeability of oxycodone base was approximately 7.4 times higher than protonated oxycodone.
    • Release rate from silicone elastomer followed Higuchi's equation (Q/t1/2 proportional to sqrt(drug loading)).
    • Skin permeation rate increased with drug loading, plateauing at 60 mg/cm3.

    Conclusions:

    • The non-ionic form of oxycodone is key for enhanced skin penetration.
    • Silicone elastomer formulations offer controlled release, with loading dose influencing permeation.
    • Findings inform the development of oxycodone transdermal delivery systems.