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Updated: Jul 11, 2026
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Solvent-controlled Csp2-->O silyl migration: the "one-pot" synthesis of 2,3-disubsituted thiophenes
Nelmi O Devarie-Baez1, Brian J Shuhler, Hua Wang
1Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
Abstract:
An effective "one-pot" synthesis of disubstituted thiophene derivatives employing 3-bromo-2-silyl thiophenes has been developed. A solvent-controlled [1,4] Csp2-->O silyl migration was involved as the key step in this process.
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