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Published on: December 10, 2010
Peptide YY regulates bone turnover in rodents
Katherine E Wortley1, Karen Garcia, Haruka Okamoto
1Regeneron Pharmaceuticals Inc, Tarrytown, New York, USA.
Gastroenterology
|October 9, 2007
Summary
Endogenous Peptide YY (PYY) is crucial for maintaining bone mass, but its role in body weight regulation is minor. PYY deficiency leads to osteopenia and increased bone loss sensitivity in female mice.
Area of Science:
- Endocrinology
- Bone Biology
- Metabolism
Background:
- Peptide YY (PYY) and pancreatic polypeptide (PPY) are neuropeptides influencing energy balance and bone mass.
- The neuropeptide Y receptor pathway is involved in key physiological processes.
- Understanding endogenous PYY and PPY roles requires targeted genetic studies.
Purpose of the Study:
- To investigate the role of endogenous PYY and PPY in regulating energy balance and bone mass.
- To characterize the physiological effects of PYY and PPY deficiency in mice.
Main Methods:
- Generated and studied Pyy-deficient (Pyy(-/-)) and Ppy-deficient (Ppy(-/-)) mice.
- Monitored food intake, metabolism, and activity via indirect calorimetry.
- Assessed body composition and bone parameters using DXA, histomorphometry, and mechanical testing.
Main Results:
- Pyy(-/-) mice exhibited an osteopenic phenotype with reduced trabecular bone mass and impaired bone strength.
- Female Pyy(-/-) mice showed increased susceptibility to ovariectomy-induced bone loss.
- No significant metabolic or bone phenotype was observed in Ppy(-/-) mice.
- Female Pyy(-/-) mice gained more weight and adiposity on a high-fat diet.
Conclusions:
- Endogenous PYY plays a critical role in regulating bone mass.
- The role of PYY in body weight regulation is minor and context-dependent (high-fat diet).
- PPY does not appear to play a significant role in bone or metabolic regulation.
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