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Updated: Jul 11, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Reduced hippocampal functional connectivity in Alzheimer disease
Greg Allen1, Holly Barnard, Roderick McColl
1Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9127, USA. Greg.Allen@UTSouthwestern.edu
Objective:
To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease.
Design:
Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain.
Participants:
Eight patients with probable Alzheimer disease and 8 healthy volunteers.
Results:
Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes.
Conclusion:
These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.
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