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Updated: Jul 11, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Influence of platelet-rich plasma on bone regeneration: a histomorphometric study in rabbit calvaria
Jesús Torres1, Isabel Tresguerres, Faleh Tamimi
1Department of Health Sciences III, Faculty of Health Sciences, Rey Juan Carlos University, Alcorcón, Madrid, Spain. chustg@yahoo.es
Purpose:
The aim of this study was to evaluate whether local application of platelet-rich plasma (PRP) would induce bone regeneration in cranial defects on rabbits.
Materials And Methods:
Twelve female New Zealand rabbits were used for this study. Two identical 10-mm-diameter bicortical cranial defects were created in each animal. One of the defects was grafted with PRP, while the contralateral was left unfilled as a negative control. Animals were sacrificed at 2, 4, 6, and 8 weeks after surgery, and biopsy specimens were evaluated histologically and histomorphometrically under light microscopy. Analysis of variance was used for statistical analysis.
Results:
The histomorphometric evaluation showed more regenerated bone after local administration of PRP at 2 weeks (P > .05), 4 weeks (P < .05), and 6 weeks (P > .05). At week 8, new bone formation was comparable in both groups.
Conclusion:
In this animal model, local application of PRP in bone defects enhances healing significantly at 4 weeks.
