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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 11, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

Nanotechnology and cancer.

James R Heath1, Mark E Davis

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA. heath@caltech.edu

Annual Review of Medicine
|October 17, 2007
PubMed
Summary

Advancing cancer research uses systems biology network models for molecular insights. Emerging nanodiagnostics and nanotherapeutics aim for accurate, cost-effective cancer detection and treatment with reduced side effects.

Area of Science:

  • Oncology
  • Systems Biology
  • Nanotechnology

Background:

  • Cancer research is shifting from phenomenological to systems biology network models.
  • Understanding cancer pathophysiology at the molecular level is crucial for clinical translation.
  • Bridging the gap between academic research and clinical application presents significant challenges.

Purpose of the Study:

  • To review emerging in vitro diagnostic technologies for cancer.
  • To discuss nanoparticle-based therapeutic approaches for cancer treatment.
  • To identify nanotherapeutic strategies enhancing efficacy and minimizing toxicity.

Main Methods:

  • Discussion of diagnostic approaches utilizing microfluidics and nanotechnology.
  • Review of current nanoparticle-based therapeutics in clinical use.

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Last Updated: May 11, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Published on: March 25, 2019

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  • Focus on high-throughput, sensitive, and cost-effective diagnostic measurements.

    • Main Results:

    • Emerging technologies offer potential for accurate, sensitive, and low-cost cancer diagnostics.
    • Nanoparticle-based therapeutics have reached clinical application.
    • Strategies are being developed to improve cancer treatment efficacy and reduce side effects.

    Conclusions:

    • Systems biology and advanced technologies are key to personalized cancer medicine.
    • Microfluidics and nanotechnology are vital for next-generation cancer diagnostics.
    • Nanotherapeutics hold promise for more effective and safer cancer treatment.