Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracellular matrix: from atomic resolution to ultrastructure.

Ioannis Vakonakis1, Iain D Campbell

  • 1Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

Current Opinion in Cell Biology
|October 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural basis of microtubule-mediated signal transduction.

Cell·2025
Same author

Phase separation of a microtubule plus-end tracking protein into a fluid fractal network.

Nature communications·2025
Same author

Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends.

The Journal of cell biology·2025
Same author

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.

Science (New York, N.Y.)·2023
Same author

Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel.

Structure (London, England : 1993)·2022
Same author

The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release.

Brain : a journal of neurology·2022
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
Same journal

Substrate selectivity as a paradigm shift in mTORC1 signaling.

Current opinion in cell biology·2026
See all related articles

The extracellular matrix (ECM) structure, vital for organisms, is challenging to study due to large fibrous polymers. Recent advances reveal how collagen, fibrillin, and fibronectin interactions assemble microm scale ECM structures.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Biomaterials Science

Background:

  • The extracellular matrix (ECM) is a complex, organized structure crucial for multicellular life.
  • High-resolution structural data exists for small ECM fragments, but large fibrous polymers remain challenging to analyze.
  • Understanding ECM component assembly is key to comprehending tissue structure and function.

Purpose of the Study:

  • To review recent advancements in understanding the structure of key ECM components.
  • To highlight the role of intermolecular interactions in ECM assembly.
  • To focus on collagen, fibrillin, and fibronectin structures.

Main Methods:

  • Literature review of recent structural studies on ECM components.
  • Analysis of data focusing on intermolecular interactions.

Related Experiment Videos

  • Integration of findings on collagen, fibrillin, and fibronectin.

    • Main Results:

    • Recent structural insights into collagen, fibrillin, and fibronectin have been achieved.
    • Intermolecular interactions are critical for the assembly of larger ECM structures.
    • The review synthesizes current knowledge on the structural organization of these ECM proteins.

    Conclusions:

    • Advances in structural biology are improving our understanding of ECM components.
    • Intermolecular forces are fundamental to the formation of microm scale ECM assemblies.
    • Further research into ECM structure will advance regenerative medicine and disease understanding.