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PHI-base update: additions to the pathogen host interaction database.

Rainer Winnenburg1, Martin Urban, Andrew Beacham

  • 1Department of Biomathematics and Bioinformatics, Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, AL5 2JQ, UK.

Nucleic Acids Research
|October 19, 2007
PubMed
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The pathogen-host interaction database (PHI-base) catalogs verified pathogenicity genes from diverse pathogens. Recent updates enhance its utility for discovering drug targets against infectious diseases and improving crop protection.

Area of Science:

  • Microbiology
  • Genetics
  • Bioinformatics

Background:

  • Pathogen-host interactions are crucial for understanding disease mechanisms.
  • Identifying virulence and effector genes is key for developing interventions.
  • Databases cataloging these genes are vital for research and drug discovery.

Purpose of the Study:

  • To describe recent updates and applications of the pathogen-host interaction database (PHI-base).
  • To highlight the expansion of PHI-base with new data fields and improved curation.
  • To showcase enhanced search functionalities and data accessibility.

Main Methods:

  • Cataloging experimentally verified pathogenicity, virulence, and effector genes.
  • Expanding database fields to include experimental methods, strain information, and external references.

Related Experiment Videos

  • Integrating anti-infective data and target genes for compound prediction.
  • Improving curation with external expert involvement.
  • Developing new search tools and providing data in XML format.

    • Main Results:

    • PHI-base now includes an almost doubled number of characterizing fields.
    • New fields cover experimental methods, strain details, pathogenicity islands, and external links.
    • Inclusion of anti-infectives and target genes enables prediction of potential drug interactions.
    • Curation process enhanced with external expert input.
    • New search tools and XML format improve data accessibility and usability.

    Conclusions:

    • PHI-base is an expanding and invaluable resource for discovering virulence genes in pathogens.
    • The database supports the identification of potential drug targets for medical and agricultural applications.
    • Enhanced features facilitate research into pathogen-host interactions and the development of novel anti-infectives.