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Updated: Jul 10, 2026

Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)
Published on: September 13, 2018
Non-invasive ventilation for cystic fibrosis.
F Moran1, J M Bradley, A P Jones
1University of Ulster, Room 14J07, School of Health Sciences, Shore Road, Newtownabbey, Northern Ireland, UK, BT37 0QB. f.moran@ulster.ac.uk
Non-invasive ventilation (NIV) may aid airway clearance and improve exercise performance in cystic fibrosis (CF). While NIV shows potential benefits for gas exchange during sleep, its long-term impact on CF progression requires further study.
Area of Science:
- Respiratory Medicine
- Clinical Trials
- Cystic Fibrosis Research
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting the lungs, leading to respiratory failure.
- Non-invasive ventilation (NIV) is explored as a method to manage respiratory compromise in CF patients.
Purpose of the Study:
- To evaluate the efficacy of non-invasive ventilation (NIV) compared to no NIV in individuals with cystic fibrosis (CF).
Main Methods:
- Systematic review of randomized controlled trials (RCTs) identified through comprehensive database searches and trial registers.
- Included trials compared pressure-preset or volume-preset NIV with no NIV in CF patients experiencing acute or chronic respiratory failure.
- Data extraction and quality assessment were performed independently by three reviewers.
Main Results:
- Seven trials involving 106 participants were analyzed.
- NIV may facilitate airway clearance and improve lung function parameters in CF patients.
- Overnight NIV showed potential for improving gas exchange during sleep and enhancing exercise performance compared to room air or oxygen therapy alone.
Conclusions:
- NIV can be a valuable adjunct to airway clearance techniques for CF patients, especially those with difficulty expectorating sputum.
- NIV may improve sleep gas exchange in moderate to severe CF disease when used with oxygen.
- Further long-term, adequately powered RCTs are needed to clarify the clinical impact of NIV on CF exacerbations and disease progression.
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