Related Experiment Video
Updated: Jul 10, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Doppler echocardiography in normally functioning replacement aortic valves: a review of 129 studies
Ronak Rajani1, Dayal Mukherjee, John B Chambers
1Valve Study Group, Guy's and St. Thomas' Foundation Trust, London, United Kingdom.
Insights
Echocardiography assesses aortic valve replacement hemodynamics. Obstructiveness varied by valve type, with caged-ball valves most obstructive and homografts least obstructive.
Area of Science:
- Cardiology
- Biomedical Engineering
- Medical Imaging
Background:
- Echocardiography is crucial for evaluating prosthetic aortic valves.
- Valve hemodynamics are influenced by design and size.
- Published data up to 2005 was reviewed.
Purpose of the Study:
- To review and compare the hemodynamic obstruction of various aortic valve replacement types.
- To identify trends in valve obstructiveness based on design and material.
Main Methods:
- Literature review of published studies on aortic valve replacement hemodynamics.
- Comparative analysis of valve obstructiveness based on reported data.
- Derivation of guide thresholds for obstruction.
Main Results:
- Caged-ball valves were the most obstructive.
- Stented porcine and single tilting-disc valves showed significant obstruction.
- Stented bovine pericardial and intra-annular bileaflet mechanical valves were less obstructive.
- Stentless valves and reduced-cuff mechanical bileaflet valves were even less obstructive.
- Homografts demonstrated the least obstruction.
Conclusions:
- Valve design significantly impacts hemodynamic function and obstruction.
- A hierarchy of obstructiveness exists among different prosthetic aortic valve types.
- Guide thresholds for identifying obstruction were established.
Abstract:
Echocardiography is the technique of choice for the assessment of replacement aortic valves. Hemodynamic function depends on the design and size of the valve. This review summarizes the published information available to the end of 2005. The most obstructive valve was the caged-ball, followed by the stented porcine and single tilting-disc valves. The stented bovine pericardial valves were slightly less obstructive than these, and similar to the intra-annular bileaflet mechanical valves. Stentless valves appeared slightly less obstructive still, and similar to reduced-cuff mechanical bileaflet valves. Homografts were the least obstructive. Approximate guide thresholds suggesting obstruction were derived.
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aortic Regurgitation I: Introduction
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Heart Valves
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

