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Sorafenib: a promising new targeted therapy for renal cell carcinoma

Laura S Wood1, Beth Manchen

  • 1Cleveland Clinic Foundation, OH, USA. woodl@ccf.org

Clinical Journal of Oncology Nursing
|October 27, 2007
PubMed

Insights

Advanced renal cell carcinoma (RCC) treatment is improving with targeted therapies like sorafenib. Oncology nurses play a key role in managing side effects for better patient outcomes.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Renal cell carcinoma (RCC) often diagnosed at advanced stages with limited treatment options and poor survival.
  • Traditional treatments like nephrectomy and immunotherapy have significant side effects and limited efficacy.
  • Emerging orally administered targeted therapies offer improved benefits for advanced RCC patients.

Observation:

  • Sorafenib, an oral multikinase inhibitor, is FDA-approved for advanced RCC.
  • Sorafenib demonstrated an extension of median progression-free survival from 12 to 24 weeks.

Findings:

  • Management of sorafenib-related side effects is crucial for patient adherence and treatment success.
  • Common side effects include skin rash, hand-foot skin reaction, hypertension, diarrhea, and fatigue.

Implications:

  • Oncology nurses require updated knowledge to effectively manage patients on sorafenib.
  • Targeted therapies like sorafenib represent a significant advancement in advanced RCC treatment.
  • Effective side effect management can improve quality of life and treatment adherence for RCC patients.

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