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Related Experiment Video

Updated: Jul 10, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

Single-step process to produce surface-functionalized polymeric nanoparticles.

Eric M Sussman1, Michael B Clarke, V Prasad Shastri

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|October 30, 2007
PubMed
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Researchers developed a novel single-step method to create functionalized polymeric nanoparticles (NPs) from nonfunctional polymers. This process allows for versatile surface engineering of NPs, crucial for drug delivery and imaging applications.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Polymeric nanoparticles (NPs) are vital for targeted drug delivery and imaging.
  • Surface functionalization of NPs is key for their efficacy but often requires complex synthesis.
  • Current methods necessitate pre-synthesis of functionalized polymers.

Purpose of the Study:

  • To develop a facile, single-step method for producing functionalized polymeric NPs from nonfunctional polymers.
  • To enable versatile surface engineering of NPs with diverse functionalities.
  • To achieve control over NP size independently of surface modification.

Main Methods:

  • Tailoring polymer solvation in a binary solvent system.
  • Adding an aqueous phase containing water-soluble polymers or polyelectrolytes.

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Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
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Last Updated: Jul 10, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
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A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates

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  • Inducing NP formation with concomitant surface functionalization.

    • Main Results:

    • Successfully produced functionalized poly(lactic-co-glycolic acid) (PLGA) NPs in a single step.
    • Demonstrated functionalization with heparin, ionic polymers, and polyethylene glycol.
    • Achieved surface coverage ranging from 3% to over 70% with controlled NP size.

    Conclusions:

    • The novel process enables efficient, single-step functionalization of polymeric NPs.
    • This method simplifies the production of complex NP surface chemistries.
    • The approach offers a versatile platform for advanced nanomedicine and imaging applications.