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Pseudoporphyria associated with voriconazole.

Wilson T Kwong1, Sylvia Hsu

  • 1Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA.

Journal of Drugs in Dermatology : JDD
|October 31, 2007
PubMed
Summary
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Pseudoporphyria, a rare photosensitivity, can be drug-induced. This case highlights voriconazole as a cause, managed effectively with sun protection in a lung transplant patient.

Area of Science:

  • Dermatology
  • Pharmacology
  • Transplantation

Background:

  • Pseudoporphyria is a photosensitive condition clinically mimicking porphyria cutanea tarda but without metabolic porphyrin abnormalities.
  • Drug-induced cases are common, necessitating identification of causative agents.

Observation:

  • A lung transplant recipient developed pseudoporphyria.
  • The condition was attributed to voriconazole, a triazole antifungal agent, which could not be discontinued.

Findings:

  • Voriconazole successfully induced pseudoporphyria in this patient.
  • Despite ongoing voriconazole treatment, the photosensitivity was controlled using broad-spectrum sunscreen (UVA and UVB protection).

Implications:

Related Experiment Videos

  • Voriconazole should be considered a potential cause of drug-induced pseudoporphyria.
  • Management strategies involving sun protection can be effective even when the offending drug is medically necessary.