Related Experiment Video
Updated: Jul 10, 2026
09:04
In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
[Hurst acute haemorrhagic leukoencephalitis: MRI findings]
L Tshibanda1, A Nchimi, M Otte
1Department of Radiology , Centre Hospitalier Universitaire, Liege, Belgium. l.tshibanda@chu.ulg.ac.be
Summary
This case report details acute hemorrhagic leukoencephalitis, a rare and rapidly fatal demyelinating disease. Advanced neuroimaging revealed characteristic lesions and microhemorrhages, correlating with autopsy findings.
Area of Science:
- Neurology
- Pathology
- Radiology
Background:
- Acute hemorrhagic leukoencephalitis (AHLE) is a rare, aggressive demyelinating disorder.
- Rapid diagnosis and understanding of AHLE are critical due to its fulminant course.
Observation:
- A case of autopsy-proven AHLE is presented.
- Early magnetic resonance imaging (MRI) demonstrated extensive, asymmetrical demyelination.
- Microhemorrhages were noted, sparing the cortical ribbon.
Findings:
- Pathological findings of AHLE were comprehensively correlated with neuroimaging.
- Advanced MRI techniques provided detailed insights into the disease's extent and characteristics.
- The disease progressed rapidly, leading to coma and death within 24 hours.
Implications:
- This case highlights the importance of early and accurate neuroimaging in diagnosing AHLE.
- Understanding the correlation between imaging and pathology aids in recognizing this rare condition.
- Further research into AHLE's pathogenesis and treatment is warranted.
Related Concept Videos
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...