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Related Experiment Videos

EUCOMM--the European conditional mouse mutagenesis program.

Roland H Friedel1, Claudia Seisenberger, Cornelia Kaloff

  • 1GSF-National Research Center for Environment and Health, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

Briefings in Functional Genomics & Proteomics
|October 31, 2007
PubMed
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The European Conditional Mouse Mutagenesis Program (EUCOMM) generates conditional mouse mutations for functional genomics. This resource aids researchers in studying gene function across various tissues and times.

Area of Science:

  • Genomics
  • Mammalian genetics
  • Functional analysis

Background:

  • Functional analysis of the mammalian genome presents significant challenges for biomedical scientists.
  • The European Conditional Mouse Mutagenesis Program (EUCOMM) was established to address these challenges.
  • A comprehensive resource of mouse mutations is crucial for advancing genetic research.

Purpose of the Study:

  • To generate a large-scale resource of conditional mouse mutations for functional genomic studies.
  • To create up to 12,000 gene-trapped and 8,000 gene-targeted mutations in mouse embryonic stem cells.
  • To develop novel Cre driver mouse lines for precise gene manipulation.

Main Methods:

  • Employing gene trapping and gene targeting in mouse embryonic stem (ES) cells to create mutations.

Related Experiment Videos

  • Developing conditional alleles that allow for Cre recombinase-mediated gene disruption.
  • Generating mouse lines from the EUCOMM resource and new Cre driver lines.

    • Main Results:

    • Generation of a substantial collection of mutant mouse embryonic stem cell lines.
    • Development of conditional alleles enabling spatio-temporal control of gene function.
    • Creation of up to 320 mouse lines and 20 new Cre driver lines.

    Conclusions:

    • The EUCOMM resource provides an invaluable, openly available collection of mutant ES cells and mice.
    • This initiative significantly facilitates the functional analysis of the mammalian genome.
    • EUCOMM is a key component of a global effort to establish a comprehensive mouse mutant resource.