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Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
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[Pathophysiology of cognitive impairment after diffuse brain injury: the prospects for cell transplantation therapy]

Katsuhiko Maruichi1, Satoshi Kuroda, Yoshinobu Iwasaki

  • 1Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 14 West 5, Kita-ku, Sapporo 060-8638, Japan. kacchin1118@hotmail.com

No Shinkei Geka. Neurological Surgery
|November 1, 2007
PubMed
Abstract

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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