Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Athletic amenorrhea and endothelial dysfunction.

Anne Z Hoch1, Jason W Jurva, Megan A Staton

  • 1Department of Orthopaedic Surgery/Cardiovascular Center, 9200 W Wisconsin Ave, Medical College of Wisconsin, Milwaukee 53226, USA. azeni@mcw.edu

WMJ : Official Publication of the State Medical Society of Wisconsin
|November 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase.

Basic research in cardiology·2025
Same author

The role of NO, H<sub>2</sub>O<sub>2</sub>, and non-NO/H<sub>2</sub>O<sub>2</sub> mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease.

Basic research in cardiology·2025
Same author

Characterization of anticancer therapy-induced microvascular dysfunction in patients with breast cancer supports targeted intervention.

JCI insight·2025
Same author

Take charge during treatment: a protocol for a pilot study to evaluate the impact of exercise on cardiovascular biomarkers among black and white breast cancer patients undergoing treatment.

Cardio-oncology (London, England)·2025
Same author

Associations with resolution of ST-segment elevation myocardial infarction criteria on out-of-hospital 12-lead electrocardiograms following resuscitation from cardiac arrest.

Resuscitation·2025
Same author

Noninvasive estimation of skeletal muscle oxygen consumption rate and microvascular reactivity in chronic stroke survivors using near-infrared spectroscopy.

Journal of applied physiology (Bethesda, Md. : 1985)·2024
Same journal

Erratum.

WMJ : official publication of the State Medical Society of Wisconsin·2026
Same journal

Proceedings From the 2025 Medical College of Wisconsin Innovations in Healthcare Education Research Annual Conference.

WMJ : official publication of the State Medical Society of Wisconsin·2026
Same journal

Starvation Ketosis Versus Euglycemic Diabetic Ketoacidosis in Pregnancy: A Case Report Highlighting the Diagnostic Overlap.

WMJ : official publication of the State Medical Society of Wisconsin·2026
Same journal

Should We Consider the Use of Buprenorphine for Pain Management in Nonsurgical Candidates With End-stage Osteoarthritis? A Case Report.

WMJ : official publication of the State Medical Society of Wisconsin·2026
Same journal

Phlegmasia Cerulea Dolens With Compartment Syndrome.

WMJ : official publication of the State Medical Society of Wisconsin·2026
Same journal

A Case of Low-Dose Ceftriaxone-Induced Liver Injury in an Adult.

WMJ : official publication of the State Medical Society of Wisconsin·2026
See all related articles

Athletic amenorrhea in college runners often resolves, leading to improved brachial artery dilation. This suggests that restoring menstrual function positively impacts vascular health in these athletes.

Area of Science:

  • Exercise Physiology
  • Cardiovascular Health
  • Reproductive Endocrinology

Background:

  • Athletic amenorrhea is common in female runners and can affect reproductive health.
  • Endothelial function, assessed by brachial artery flow-mediated dilation, is a marker of cardiovascular health.
  • The long-term impact of resolving athletic amenorrhea on vascular function is not well understood.

Purpose of the Study:

  • To investigate changes in menstrual status in college runners with athletic amenorrhea over a 2-year period.
  • To determine the effect of altered menstrual status on brachial artery flow-mediated dilation.

Main Methods:

  • Follow-up study of 18 female athletes (9 amenorrheic, 9 eumenorrheic/control) 2 years after baseline measurements.
  • Menstrual status determined via questionnaires, interviews, and blood draws.

Related Experiment Videos

  • Brachial artery flow-mediated dilation measured using non-invasive ultrasound.

    • Main Results:

    • Menstrual status normalized in 7 of 9 original amenorrheic subjects.
    • Brachial artery flow-mediated dilation significantly improved in the previously amenorrheic group (1.1% to 5.6%, P=0.01).
    • No significant change in flow-mediated dilation was observed in the eumenorrheic/control group (6.3% to 8.0%, P=0.42).

    Conclusions:

    • Menstrual status changes were observed in a majority of amenorrheic athletes.
    • Restoration of menstrual function was associated with improved endothelial-dependent brachial artery dilation.
    • These findings highlight the link between reproductive health and cardiovascular function in female athletes.