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[Effects of BCG-PSN injection on immune and lung function of asthmatic children complicated with allergic rhinitis]

Jing-Zhi Ji1, Zhuang-Gui Chen, Yan-Feng Chen

  • 1Department of Pediatrics, The Third Affiliated Hospital, Sun Yet-Sen University, Guangzhou, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|November 1, 2007
PubMed

Insights

Polysaccharide nucleic acid of BCG (BCG-PSN) improved immune balance and lung function in children with asthma and allergic rhinitis. This suggests immune-adjusting therapy is crucial alongside anti-inflammatory treatments.

Area of Science:

  • Immunology
  • Pediatric Pulmonology
  • Allergy

Context:

  • Asthma and allergic rhinitis are common in children, often involving Th2-dominant immune responses.
  • Current treatments primarily focus on anti-inflammation, potentially neglecting immune dysregulation.

Purpose:

  • To evaluate the efficacy of polysaccharide nucleic acid of BCG (BCG-PSN) in modulating immune function and improving pulmonary parameters in pediatric patients with comorbid asthma and allergic rhinitis.

Summary:

  • A randomized controlled trial compared BCG-PSN plus inhaled corticosteroids (n=17) against inhaled corticosteroids alone (n=20) for 6 months.
  • BCG-PSN treatment significantly increased IFN-g, improved the IFN-g/IL4 ratio, decreased IL-4 and total IgE, reduced asthmatic attacks and respiratory infections, and enhanced lung function compared to controls.

Impact:

  • BCG-PSN demonstrates potential in correcting Th1/Th2 imbalance in pediatric asthma with allergic rhinitis.
  • Findings highlight the importance of immune-modulating therapies in managing complex respiratory conditions in children.
Abstract

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