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Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
Published on: November 14, 2018
Dynamics of diamond nanoparticles in solution and cells
Felix Neugart1, Andrea Zappe, Fedor Jelezko
1Physikalisches Institut University of Stuttgart, Stuttgart, Germany.
Nano Letters
|November 3, 2007
Summary
Single diamond nanocrystals exhibit distinct motional dynamics in buffer and cells. Nanocrystals aggregate in response to pH changes but can be stabilized with surfactants, showing potential for cellular applications.
Area of Science:
- Nanotechnology
- Biophysics
- Materials Science
Background:
- Diamond nanocrystals offer unique optical and physical properties.
- Understanding their behavior in solution and biological environments is crucial for applications.
Purpose of the Study:
- To investigate the fluorescence and motional dynamics of single diamond nanocrystals.
- To assess their behavior in buffer solutions and living cells.
Main Methods:
- Fluorescence correlation spectroscopy (FCS) was used to study nanodiamonds.
- Atomic force microscopy (AFM) was employed for size validation.
Main Results:
- Effective hydrodynamic radius indicated a 48 nm particle diameter, matching AFM.
- Nanocrystals readily aggregated with pH changes, a tendency reduced by surfactants.
- Cells internalized nanocrystals, which distributed uniformly and became immobilized.
- Streptavidin binding to biotinylated nanodiamond aggregates was confirmed.
Conclusions:
- Diamond nanocrystals demonstrate controllable aggregation behavior in solution.
- Their uptake and distribution in cells suggest potential for intracellular applications.
- The study provides insights into nanodiamond dynamics for bio-imaging and drug delivery.
