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Updated: Jul 10, 2026
Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons
Published on: August 17, 2012
NgR acts as an inhibitor to axonal regeneration in adults
Shuyan Zhang1, Qinli Zhang, John H Zhang
1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing (400016), China.
Abstract:
After injury to the central nervous system (CNS) in adults, axonal regeneration is confined, in part, by the inhibitory factors in CNS myelin, including Nogo-A protein, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMGP). These proteins, all bind to the same neuronal glycosylphosphatidylinositol-anchored receptors (NgR), and transduce inhibitory signals to cells by the transmembrane co-receptor, p75. The final outcome of this event is inhibition of axonal regeneration and recovery of locomotion. Based on these findings, one avenue for promotion of axonal regeneration is by virtue of blocking the inhibitory effects of NgR.
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