The stability of proton T2 effects of oxygen-17 water in experimental cerebral ischemia
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A L Hopkins1, W D Lust, E M Haacke
1Department of Anatomy, Case Western Reserve University, Cleveland, Ohio.
Magnetic Resonance in Medicine
|November 1, 1991
Abstract:
The gerbil model of unilateral cerebral ischemia has been used to test the temporal and spatial stability of the MRI T2 effects of oxygen-17 water. Following unilateral carotid ligation, symptomatic animals were given a single large intraperitoneal injection of H2(17)O and the distribution and stability of the brain T2 effects were followed with a spin-echo sequence. In contrast to the ischemic areas, the perfused tissue shows a marked and prolonged loss in intensity with little evidence of diffusion of the T2 effect of 17O into the ischemic tissue.