Calcium and bone metabolism pre- and post-kidney transplantation

Chronic kidney disease (CKD) is associated with significant disturbances in bone and mineral metabolism, the manifestations of which are heterogeneous in their expression and clinical impact. Over the last 2 decades, advances in the management of CKD and improved outcomes of kidney transplantation have led to the emergence of post-transplantation bone disease as a serious cause of morbidity in long-term survivors. The management of post-kidney transplantation bone disease represents a difficult challenge because of its complex pathophysiology and the paucity of clinical data on effective therapies. The optimal management of disturbances of bone and mineral metabolism before kidney transplantation forms the cornerstone of their successful management after transplantation. Therapeutic strategies to effectively and safely decrease skeletal morbidity after kidney transplantation are not yet clearly established.