Related Experiment Video
Updated: Jul 10, 2026

Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method
Published on: July 19, 2019
A "HOWFARLESS" option to increase efficiency of homogeneous phantom calculations with DOSXYZnrc
1Ionizing Radiation Standards, National Research Council of Canada, Ottawa K1A OR6.
Abstract:
This paper describes a "HOWFARLESS" transport option, which has been added to DOSXYZnrc to increase the efficiency of beam commissioning calculations in homogeneous phantoms. The algorithm speeds up charged particle transport by only considering the distance to the extreme outer boundaries of the phantom, thus eliminating the need to stop at voxel boundaries. Dose is deposited by approximating the total curved charged particle steps by two straight-line steps joined at a hinge point. Good agreement with normal simulations is achieved at all beam energies and for all practical maximum step lengths with a 1:1 mixture of approximations based on the initial position/ direction of the particle and on its final position/direction. Use of the "HOWFARLESS" option in phantom calculations for 6 and 18 MV photon beams (10 x 10 cm2 and 40 x 40 cm2 fields) from BEAMnrc-simulated accelerators increases the efficiency at the optimum photon splitting number by a factor of 2.9-5.4 when the exact EGSnrc boundary crossing algorithm (BCA) is used and by 51%-89% when the faster PRESTA-I BCA is employed. The efficiency gain due to the "HOWFARLESS" transport option increases with increasing beam energy and decreases with increasing field/dose voxel size. Efficiency improvement is greater when the efficiency of the particle source itself is not a factor, and in such cases the "HOWFARLESS" option improves the DOSXYZnrc efficiency by up to a factor of 13.1 (exact BCA) or 3.5 (PRESTA-I BCA) for photon beams, and up to a factor of 17.2 (exact BCA) or 5.2 (PRESTA-I BCA) for electron beams.
Related Concept Videos
Dosage Regimens: Partial Pharmacokinetic Parameters
Dose Size and Dosing Frequency: Determination Methods
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters
One key aspect of the noncompartmental approach is determining a drug's total clearance. This can be done by dividing the drug dose by the area under the concentration-time curve from zero to infinity. The area under the concentration-time curve represents the drug's overall...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Optimizing Chromatographic Separations
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...

