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Updated: Jul 10, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
Published on: November 19, 2012
Gradual changes in hippocampal activity support remembering the order of events
Joseph R Manns1, Marc W Howard, Howard Eichenbaum
1Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
Abstract:
The hippocampus is thought to contribute to episodic memory in part by binding stimuli to their spatiotemporal context. The present study examined how hippocampal neuronal populations encode spatial and temporal context as rats performed a task in which they were required to remember the order of trial-unique sequences of odors. The results suggest that a gradual change in the pattern of hippocampal activity served as a temporal context for odor-sampling events and was important for successful subsequent memory of the order of those odors.
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