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Updated: Jul 10, 2026
06:31
Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts
Published on: September 27, 2018
[Extended cycle oral contraceptives].
1Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem. rgeist@isdn.net.il
Harefuah
|November 10, 2007
Summary
Extended cycle oral contraception offers a safe and effective alternative to monthly bleeding, aligning with patient preferences for fewer menstrual cycles. This approach maintains pregnancy prevention without increasing major health risks.
Area of Science:
- Reproductive Health
- Gynecology
- Pharmacology
Context:
- Conventional oral contraceptive (OC) prescriptions induce monthly withdrawal bleeding, a practice rooted in historical reasons rather than medical necessity.
- Patient demand for reduced menstrual cycle frequency is evident.
- Continuous OC administration has been observed to be feasible and safe in clinical practice.
Purpose:
- To review the existing literature on extended cycle oral contraception, encompassing regimens up to one year.
- To assess the safety and efficacy of continuous OC administration compared to conventional cyclic use.
Summary:
- Extended cycle oral contraception, administered continuously for up to one year, does not compromise pregnancy prevention efficacy.
- This regimen is not associated with increased cardiovascular, hemostatic, or endometrial malignancy risks.
- While a slight increase in breast cancer risk exists with long-term OC use (up to 10 years) irrespective of administration method, extended cycling shows a favorable side effect profile, primarily marked by increased breakthrough bleeding but reduced withdrawal bleeding.
Impact:
- Provides evidence supporting extended cycle oral contraception as a viable option for women seeking less frequent menstruation.
- Highlights the safety profile of continuous OC use, addressing potential concerns regarding cardiovascular and hemostatic complications.
- Informs clinical practice and patient counseling regarding the benefits and side effects of extended cycle oral contraceptive regimens.
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