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Updated: Jul 10, 2026
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Identified a novel allele HLA-A*240212 by sequence-based typing
1HLA Laboratory, Beijing Red Cross Blood Center, Beijing, China. liuna_beijingchina@yahoo.com.cn
Tissue Antigens
|November 10, 2007
Summary
A new human leukocyte antigen-A allele, A*240212, was discovered in a Chinese Marrow Donor Program participant. This novel allele differs from A*24020101 by a single, silent nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular biology
- Hematology
Background:
- Human leukocyte antigen (HLA) genes are crucial for immune response and transplantation.
- Accurate HLA typing is essential for successful hematopoietic stem cell transplantation.
- The HLA-A locus is highly polymorphic and frequently typed.
Purpose of the Study:
- To report the identification and characterization of a novel HLA-A allele.
- To document a new allele for the Chinese Marrow Donor Program registry.
Main Methods:
- Routine sequence-specific oligonucleotide typing (SSO).
- Sequence-based typing (SBT).
- Nucleotide sequence analysis.
Main Results:
- A novel HLA-A allele, designated A*240212, was identified.
- This allele differs from A*24020101 by a single nucleotide substitution at position 230 in Exon 2.
- The identified nucleotide exchange represents a silent mutation.
Conclusions:
- The discovery of HLA-A*240212 expands the known HLA-A allele repertoire.
- This finding contributes to the genetic diversity information within the Chinese population.
- Accurate HLA allele identification is vital for donor-recipient matching in marrow transplantation.
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