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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells

Amit Awasthi1, Yijun Carrier, Jean P S Peron

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA.

Nature Immunology
|November 13, 2007
PubMed
Summary

Regulatory T cells (Treg cells) are crucial for immune balance. This study reveals IL-27 and TGF-beta drive the induction of IL-10-producing Tr1 cells, key for immune suppression.

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