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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
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Computed Tomography (CT) scan:
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Related Experiment Video

Updated: Jul 10, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

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Published on: July 24, 2020

Optical coherence tomography--high resolution imaging of structure and function.

Rainer A Leitgeb1

  • 1Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. rainer.leitgeb@epfl.ch

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 16, 2007
PubMed
Summary

Optical coherence tomography (OCT) is a key biomedical imaging tool offering micrometer resolution, bridging tomography and microscopy. Doppler OCT advances reveal micro-vascular retinal flow, crucial for early disease detection like diabetes.

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Area of Science:

  • Biomedical Imaging
  • Optical Engineering
  • Medical Diagnostics

Background:

  • Optical coherence tomography (OCT) has emerged as a vital biomedical imaging modality.
  • Advancements in detector and light source technology have significantly enhanced OCT capabilities.
  • OCT bridges the resolution gap between macroscopic tomography (CT, MRI) and microscopy.

Purpose of the Study:

  • To highlight the diverse applications of OCT in tissue imaging and microscopy.
  • To demonstrate the utility of phase information derived from OCT for enhanced contrast and perfusion analysis.
  • To present functional imaging results using Doppler OCT for micro-vascular assessment.

Main Methods:

  • Utilizing interferometry principles for high-resolution tissue imaging.
  • Leveraging sample phase information for improved contrast and velocity-sensitive perfusion measurements.
  • Employing Doppler OCT to visualize and quantify micro-vascular retinal blood flow in 3D.

Main Results:

  • Demonstrated OCT's capability for detailed tissue imaging and microscopy applications.
  • Showcased the extraction of perfusion parameters with high velocity sensitivity using phase information.
  • Presented 3D volumetric Doppler OCT results of retinal micro-vascular flow.

Conclusions:

  • OCT is a powerful tool for biomedical imaging, offering unique phase information.
  • Functional OCT extensions, like Doppler OCT, have significant clinical relevance for disease monitoring.
  • Future OCT research promises further advancements in imaging and diagnostic capabilities.