Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An efficient algorithm for current source localization with tetrodes.

Chang Won Lee1, Hieu Dang, Zoran Nenadic

  • 1Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. cwlee@uci.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current Evidence and Clinical Implications of Full-Endoscopic Spine Surgery for Post-Vertebroplasty Lumbar Radiculopathy: A Comprehensive Review.

Journal of pain research·2026
Same author

Perception of brain-computer interface implantation surgery for motor, sensory, and autonomic restoration in spinal cord injury and stroke.

Frontiers in neuroscience·2026
Same author

Real-time brain-computer interface control of walking exoskeleton with bilateral sensory feedback.

Brain stimulation·2026
Same author

Robotic Ankle Assessment Post-Stroke: Reliability, Comparison to Therapists, and Benchmark Dataset Development.

Sensors (Basel, Switzerland)·2025
Same author

The Weak Relationship Between Ankle Proprioception and Gait Speed After Stroke: A Robotic Assessment Study.

Neurorehabilitation and neural repair·2025
Same author

Clinical Characteristics and Epidemiology of Cardiovascular Autonomic Neuropathy in Peoples With Long-Standing Diabetes.

Journal of Korean medical science·2025
Same journal

Analysis of End-Tidal CO2 Variability During Plateau Waves Episodes: An Information Theoretic Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

AI and Tomosynthesis for Breast Cancer Molecular Subtyping: A step toward precision medicine<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Towards Sustainable Protein Recovery from Biological Waste: Assessing Polyethersulfone-based Microfiltration.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of the cardiovascular response to standardized polymicrobial peritonitis experimental model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Automated Wrist Ultrasound Image Bone Enhancement and Segmentation Using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
See all related articles

We developed a new algorithm to pinpoint electrical source locations in neurons using action potential data from multiple sensors. This method accurately estimates both the location and strength of neuronal current sources.

Area of Science:

  • Neuroscience
  • Computational Biology
  • Signal Processing

Background:

  • Accurate localization of electrical sources within neurons is crucial for understanding neuronal function.
  • Current methods for source localization can be complex and may not cover all scenarios.

Purpose of the Study:

  • To develop a simple and accurate algorithm for localizing electrical sources in neurons.
  • To simultaneously estimate source location and strength.

Main Methods:

  • Utilized multiple measurements of neuron action potentials from sensors like tetrodes.
  • Developed an analytical solution for source localization where applicable.
  • Formulated an alternative approach for cases where analytical solutions are not feasible.
  • Tested the algorithm on a single-neuron model with complex dendritic geometry and realistic membrane dynamics.

Related Experiment Videos

Main Results:

  • Demonstrated that neuronal source localization can often be solved analytically.
  • Showed that source localization and strength estimation are coupled and can be solved together.
  • Simulation results confirmed the technique's accuracy in estimating location and strength of nearby current sources.

Conclusions:

  • The developed algorithm provides an effective method for neuronal electrical source localization.
  • The technique accurately estimates both the position and magnitude of neuronal current sources.
  • This approach offers a valuable tool for neuroscientists studying neuronal electrical activity.