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Updated: Jul 10, 2026

Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo
Published on: November 10, 2023
Closed neural tube defects: neurologic, orthopedic, and gait outcomes
Marilyn Ross1, Kelly Brewer, F Virginia Wright
1Bloorview Kids Rehab, Toronto, Ontario, Canada. mross@bloorview.ca
Purpose:
The purpose of our study was to obtain a clear understanding of the various diagnoses within the closed neural tube defect (NTD) groups included in the large database of clients in our Spina Bifida Clinic and a clear picture of the outcomes for the various NTD groups.
Methods:
One hundred and four clients with closed NTD were categorized using a classification system devised by Tortori-Donati et al. Various clinical markers were investigated, including ambulation and the need for orthoses and wheelchairs.
Results:
Most clients are ambulatory, requiring an orthoses, but not a wheelchair, despite the high incidence of ankle/foot abnormalities.
Conclusions:
This classification system has enhanced our knowledge of this group of clients, provided a greater understanding of the varied outcomes of these children and clinical management required.
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