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Separation processes for organic molecules using SCF Technologies.

L S Daintree1, A Kordikowski, P York

  • 1ParticlesCIC, University of Leeds, Houldsworth Building, Leeds LS2 9JT, United Kingdom. L.Daintree@leeds.ac.uk

Advanced Drug Delivery Reviews
|November 17, 2007
PubMed
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Supercritical fluid extraction offers efficient separation and purification for pharmaceutical molecules. This review covers its applications in impurity control, polymorphism, and chiral resolution, highlighting its value in producing high-purity compounds.

Area of Science:

  • Chemical Engineering
  • Pharmaceutical Sciences
  • Analytical Chemistry

Background:

  • Supercritical fluids (SCFs) are extensively used for solute separation from solids and mixtures.
  • Impurity control is critical in pharmaceuticals to maintain chemical properties and physical stability.
  • SCF applications are vital for producing pure, pharmaceutically relevant organic molecules.

Purpose of the Study:

  • To review the literature on SCF applications for separating and purifying pharmaceutically important molecules.
  • To discuss SCF use in controlling process impurities, polymorphic forms, and chiral resolution.
  • To provide an overview of selective chemical reactions in SCFs for pharmaceutical synthesis.

Main Methods:

  • Literature review of supercritical fluid extraction (SFE) and related techniques.

Related Experiment Videos

  • Analysis of SCF applications in pharmaceutical purification and impurity control.
  • Examination of SCFs in polymorphism, chiral resolution, and chemical synthesis.

    • Main Results:

    • SCFs are effective for separating and purifying diverse pharmaceutical compounds.
    • SCF applications extend to controlling process impurities, residual solvents, and polymorphic forms.
    • SCFs facilitate chiral resolution and highly selective chemical reactions.

    Conclusions:

    • Supercritical fluid technology is a versatile tool for pharmaceutical purification and synthesis.
    • SCFs enable precise control over impurity profiles, solid-state forms, and enantiomeric purity.
    • Further exploration of SCFs in pharmaceutical manufacturing promises advancements in drug quality and development.