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Prism-coupled multimode waveguide refractometer.

Zhi-Mei Qi, Naoki Matsuda, Jose H Santos

    Optics Letters
    |November 17, 2007
    PubMed
    Summary
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    A novel optical sensor uses a prism-coupled waveguide to measure liquid refractive index (RI). This refractometer achieves high resolution, enabling real-time detection of biomolecular interactions.

    Area of Science:

    • Optical Physics
    • Materials Science
    • Biophysics

    Background:

    • Refractometers are crucial for measuring the refractive index (RI) of liquids.
    • Existing methods may lack sensitivity for detecting thin layers or real-time interactions.
    • Optical waveguides offer potential for sensitive RI measurements.

    Purpose of the Study:

    • To develop a new refractometer based on prism-coupled multimode planar waveguides.
    • To achieve high-resolution RI detection for liquid samples.
    • To demonstrate the sensor's capability for real-time biomolecular interaction monitoring.

    Main Methods:

    • Utilized a prism-coupled multimode planar waveguide (quartz plate on PMMA support) with a flow cell.
    • Measured changes in the effective refractive index (RI) of the highest-order TE/TM mode.

    Related Experiment Videos

  • Monitored the resonant angle and output light intensity to detect RI variations.

    • Main Results:

    • Demonstrated a refractive index resolution of 3x10(-5) for aqueous solutions.
    • Theoretical calculations suggest detection of 0.5-nm-thick adsorbed monolayers.
    • The sensor effectively detects RI changes in a wide range.

    Conclusions:

    • The developed optical sensor provides high-resolution RI measurements.
    • Its sensitivity is suitable for detecting thin adsorbed layers.
    • The sensor is well-suited for real-time monitoring of biomolecular interactions.