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Updated: Jul 10, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Annular fundus autofluorescence abnormality in a case of macular dystrophy
Charlotte M Poloschek1, Lutz L Hansen, Michael Bach
1Department of Ophthalmology, University of Freiburg, Killianstr. 5, 79106 Freiburg, Germany. charlotte.poloschek@uniklinik-freiburg.de
Purpose:
To present a case of macular dystrophy with early changes in fundus autofluorescence.
Methods:
A 20-year-old woman with a recent loss of visual acuity and onset of photophobia was examined. Color vision and visual field testing, fluorescein angiography, full-field and multifocal electroretinograms as well as fundus autofluorescence were performed.
Results:
Best-corrected visual acuity was 20/100 (right eye) and 20/60 (left eye). There was a red-green color vision defect and a relative central scotoma in both eyes. Ophthalmoscopy and fluorescein angiography were essentially normal, the presence of a dark choroid was debatable. Full-field ERG responses were normal, but the multifocal ERG showed severely reduced responses in the macular region. Both eyes showed a slight circular parafoveolar increase of fundus autofluorescence.
Conclusion:
Besides multifocal ERG, fundus autofluorescence aids to objectively assess the manifestation of macular dystrophies but does not discern between different types in early stages.
