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Updated: Jul 10, 2026
Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment
Published on: January 24, 2020
Selective antitumor activity of lymphokine-activated killer cells in vitro
O S Zhukova1, O V Lebedinskaya, I Zh Shubina
1Laboratory of Cell-Mediated Immunity, N. N. Blokhin National Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
Abstract:
We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphokine-activated cells and mononuclear leukocytes had no lytic effect on non-transformed eukaryotic cells. Hence, we demonstrated selective cytotoxic activity of effector cells (lymphokine-activated killers) towards tumor cells of different origin (but not normal cells).
