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Updated: Jul 10, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Inflammatory bowel disorders: current and future drugs that modulate adhesion molecules
1Department of Gastroenterology, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Leukocyte adhesion molecules are altered in inflammatory bowel diseases, suggesting they are potential therapeutic targets. Research is ongoing to develop new drugs that modulate these molecules for treating inflammatory disorders.
Area of Science:
- Immunology
- Gastroenterology
- Pharmacology
Background:
- Leukocyte infiltration into the mucosa characterizes inflammatory bowel disorders like Crohn's disease and ulcerative colitis.
- Leukocyte migration is mediated by interactions between circulating leukocytes and vascular endothelium via adhesion molecules.
Purpose of the Study:
- To explore the role of adhesion molecules in inflammatory bowel disorders.
- To investigate adhesion molecules as potential therapeutic targets for inflammatory conditions.
Main Methods:
- Review of evidence for altered adhesion molecule expression and function in inflammatory bowel disorders.
- Analysis of existing anti-inflammatory drugs' effects on adhesion molecules.
- Overview of ongoing research in developing novel adhesion molecule modulators.
Main Results:
- Adhesion molecule expression and function are significantly altered in inflammatory bowel disorders.
- Existing anti-inflammatory drugs can modulate adhesion molecule activity.
- Development of selective adhesion molecule modulators is an active area of research.
Conclusions:
- Adhesion molecules represent promising therapeutic targets for inflammatory bowel disorders.
- Targeting adhesion molecules may lead to novel and effective treatments for various inflammatory conditions.
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