Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fast Evaluation of Viral Emerging Risks (FEVER): A computational tool for biosurveillance, diagnostics, and mutation typing of emerging viral pathogens.

PLOS global public health·2023

Same author

Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults.

The Journal of clinical investigation·2023

Same author

Optical Biosensor Platforms Display Varying Sensitivity for the Direct Detection of Influenza RNA.

Biosensors·2021

Same author

Formulation of stabilizer-free, nontoxic PLGA and elastin-PLGA nanoparticle delivery systems.

International journal of pharmaceutics·2021

Same author

Vaccine Advances against Venezuelan, Eastern, and Western Equine Encephalitis Viruses.

Vaccines·2020

Same author

Resources to Discover and Use Short Linear Motifs in Viral Proteins.

Trends in biotechnology·2019

Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026

Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026

Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026

Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026

Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026

Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 9, 2026

Investigating Bacterial-Fungal Interactions using Fungal Highway Columns in Diverse Environments and Substrates

Investigating Bacterial-Fungal Interactions using Fungal Highway Columns in Diverse Environments and Substrates

Published on: January 24, 2025

The hepatitis C sequence database in Los Alamos.

Carla Kuiken¹, Peter Hraber, James Thurmond

¹HCV database, Los Alamos National Laboratory, Los Alamos, NM, USA. kuiken@lanl.gov

Nucleic Acids Research

|November 21, 2007

Summary

This summary is machine-generated.

A new Hepatitis C virus (HCV) database offers a central resource for scientists, providing annotated sequences and analysis tools to aid in understanding this rapidly evolving virus.

More Related Videos

Detection of Human Immunodeficiency Virus Type 1 HIV-1 Antisense Protein ASP RNA Transcripts in Patients by Strand-Specific RT-PCR

Detection of Human Immunodeficiency Virus Type 1 HIV-1 Antisense Protein ASP RNA Transcripts in Patients by Strand-Specific RT-PCR

Published on: November 27, 2019

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

Published on: September 21, 2012

Related Experiment Videos

Last Updated: Jan 9, 2026

Investigating Bacterial-Fungal Interactions using Fungal Highway Columns in Diverse Environments and Substrates

Investigating Bacterial-Fungal Interactions using Fungal Highway Columns in Diverse Environments and Substrates

Published on: January 24, 2025

Detection of Human Immunodeficiency Virus Type 1 HIV-1 Antisense Protein ASP RNA Transcripts in Patients by Strand-Specific RT-PCR

Detection of Human Immunodeficiency Virus Type 1 HIV-1 Antisense Protein ASP RNA Transcripts in Patients by Strand-Specific RT-PCR

Published on: November 27, 2019

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

Published on: September 21, 2012

Area of Science:

Virology
Bioinformatics
Public Health

Background:

The Hepatitis C virus (HCV) poses a significant global health challenge due to its high variability and rapid evolution.
This genetic diversity complicates immune system targeting, vaccine development, and antiviral drug design.
Over 50,000 HCV sequences have been published, highlighting the need for centralized data management.

Purpose of the Study:

To establish a centralized, publicly accessible database for annotated Hepatitis C virus (HCV) sequences.
To provide essential sequence analysis tools for the global HCV research community.
To facilitate a deeper understanding of HCV evolution and inform future therapeutic strategies.

Main Methods:

Collection and annotation of publicly available Hepatitis C virus (HCV) sequence data.
Development of a user-friendly website interface for data access and retrieval.
Integration of a comprehensive suite of sequence analysis tools, modeled after the Los Alamos HIV database.

Main Results:

A comprehensive HCV sequence database has been established and made publicly accessible.
The website features a user-friendly search interface for efficient data exploration.
A wide array of sequence analysis tools are available to support scientific research.

Conclusions:

The new HCV database serves as a vital resource for researchers worldwide.
Centralized access to annotated sequences and analysis tools will accelerate HCV research.
This initiative aims to improve the understanding and control of Hepatitis C virus infections.