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SNPs typing based on the formation of fluorescent signaling DNA aptamers which bind to bile acids

Teru Kato1, Saori Kamoto, Masumi Hyuga

  • 1School of Bionics, Tokyo University of Technology, 1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan. kato@bs.teu.ac.jp

Nucleic Acids Symposium Series (2004)
|November 22, 2007
PubMed

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Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...