Synthesis of 4'-selenoribonucleosides
Yusuke Inagaki1, Noriaki Minakawa, Akira Matsuda
1Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12, Nishi 6, Kitaku, Sapporo 0600812, Japan.
Abstract:
We report herein the synthesis and structural aspects of 4'selenouridine (11) and 4'-selenocytidine (13), novel nucleoside derivatives. 4'Selenouridine (11) was synthesized via the stereoselective seleno-Pummerer reaction between an appropriately protected selenoxide 9 and a persilylated uracil. 4'-Selenocytidine (13) was prepared from 4'selenouridine derivative 10. To the best of our knowledge, this is the first example concerning introduction of a heterocycle into the alpha- position of a seleno atom.
More Related Videos
Related Concept Videos
Biosynthesis of Nucleic Acids
Preparation and Reactions of Sulfides
Ribosomal RNA Synthesis
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosomal RNA Synthesis
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
RNA Structure
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...


