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Updated: Jul 10, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Reversible control of DNA hybridization by photoresponsive ligands
Shin-Nosuke Uno1, Chikara Dohno, Mika Oku
1The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.
Abstract:
Mismatch binding ligands (MBL) can act as a molecular glue which brings two single stranded DNAs (ssDNA) together to form a double stranded DNA (dsDNA). We here demonstrate that photoresponsive MBL possessing a photochromic azobenzene chromophore can control duplex stability reversibly in response to external light stimuli. Synthesis and evaluation of a series of NCDA derivatives reveals significant correlation between the linker structures in MBLs and the molecular glue function.
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