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Published on: January 19, 2019
Further stabilization of the double stranded DNA complex by naphthalene diimide derivative having
Sadayoshi Watanabe1, Keiichi Ohtsuka, Shigeori Takenaka
1Department of Applied Chemistry, Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cyo, Tobata-ku, Kitakyushu-shi, Fukuoka 804-8550, Japan.
Abstract:
Designed naphthalene diimide derivative having 2,2-dipicolylamine (Dpa), NDI-Dpa, could form a Zn(2+) complex and bind to calf thymus DNA with 10-times higher stabilization than that of NDI-Dpa. The obtained SDS-driven dissociation rate constant was 1.0 s(-1), which is smaller than that of NDI-Dpa. These results suggested that NDI-Dpa-Zn can bind to double stranded DNA through threading intercalation and its complex was stabilized by the interaction of Dpa-Zn parts of NDI-Dpa-Zn and phosphodiester parts of dsDNA.
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