[Results with a new type ossicular prostheses mixed bone morphogenetic protein and hydroxyapatite]

Area of Science:

• Otolaryngology
• Biomaterials Science
• Regenerative Medicine

Background:

• Ossicular chain reconstruction is crucial for restoring hearing in middle ear pathologies.
• Traditional prostheses and autografts have limitations, including extrusion and variable success rates.

Purpose of the Study:

• To evaluate the efficacy and safety of a novel ossicular prosthesis composed of hydroxyapatite and bone morphogenetic protein (HA-BMP).
• To assess hearing outcomes and complication rates in patients undergoing ossiculoplasty with HA-BMP prostheses.

Main Methods:

• A retrospective analysis of 59 ossiculoplasty cases was conducted.
• Ossiculoplasty was performed using HA-BMP prostheses (26 ears), partial ossicular replacement prostheses (PORP) (19 ears), and total ossicular replacement prostheses (TORP) (7 ears).

Main Results:

• The HA-BMP prosthesis group achieved a hearing success rate of 92.3% (24 out of 26 ears).
• No extrusion complications were observed in the HA-BMP group.
• A significant difference in the mean postoperative air-bone gap was noted between HA-BMP prostheses and autograft bone.

Conclusions:

• The novel HA-BMP prosthesis demonstrates a high success rate and stability in hearing results over time.
• This new biomaterial offers a promising alternative for ossicular chain reconstruction with a low complication profile.