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Updated: Jul 9, 2026
Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards
Published on: September 3, 2020
[The electroretinogram of infants with nystagmus]
Shizhou Huang1, Dezheng Wu, Tianqin Guan
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Insights
Electroretinogram (ERG) testing revealed significant retinal abnormalities in 91% of infants with nystagmus. These findings suggest retinal dysfunction plays a key role in the development of nystagmus in infants.
Area of Science:
- Ophthalmology
- Neuroscience
- Pediatrics
Context:
- Infantile nystagmus is an involuntary eye movement condition.
- Early diagnosis and understanding of underlying causes are crucial for management.
- Electroretinography (ERG) assesses retinal function.
Purpose:
- To characterize electroretinogram (ERG) findings in infants diagnosed with nystagmus.
- To evaluate the clinical utility of ERG in identifying retinal abnormalities associated with infantile nystagmus.
Summary:
- This study analyzed ERG responses in 46 infants (2-72 months old) with nystagmus using the ISCEV standard.
- High rates of ERG abnormalities were observed across various tests, including rod, cone, and flicker responses.
- Significant retinal dysfunction was detected in 91% of the infants, with specific patterns of rod and cone ERG reduction.
Impact:
- ERG is a valuable tool for detecting retinal dysfunction in infants with nystagmus.
- Findings highlight the significant role of retinal abnormalities in the pathogenesis of infantile nystagmus.
- This research aids in understanding the etiology of nystagmus and informs potential diagnostic and therapeutic strategies.
Purpose:
To find the characteristics and clinical application of electroretinogram (ERG) in infants with nystagmus.
Method:
Forty-six cases (92 eyes) of infants with nystagmus (aged 2-72 months old) were tested with Neuropack MEB-2200K system according to the ERG standard of ISCEV.
Results:
Five kinds of ERG responses of all subjects but one could be recorded. The abnormal rates of the rod ERG, standard mixture ERG, oscillatory potentials, single-flash cone ERG and 30 Hz flicker response were 65%, 86%, 61%, 77% and 62% respectively. The ERG abnormalities were evaluated from the 5 responses. The rod ERG decreased in 5 eyes. The rod-cone ERG decreased in 11 eyes. The cone ERG decreased in 14 eyes. The cone-rod ERG decreased in 23 eyes. The standard mixture ERG decreased in 8 eyes. The ERG was unrecordable in 8 eyes. The mild, middle, and severe decreases of rod and cone ERG appeared in 5 eyes respectively. The normal ERG was only recorded in 8 eyes.
Conclusion:
Abnormal rate of ERG is 91% in infants with nystagmus. The retina abnormality may pay an important role in the pathogenesis of nystagmus.
