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Updated: Jul 9, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Association between proliferative scars and in-stent restenosis
Cagdas Ozdol1, Sibel Turhan, Cansin Tulunay
1Cardiology Department, Ankara University School of Medicine, Ankara, Turkey. cagdas_2005@yahoo.com
Journal of Cutaneous Medicine and Surgery
|November 29, 2007
Summary
Patients with proliferative scars may face a higher risk of in-stent restenosis after coronary stenting. This study highlights a potential link between abnormal wound healing and cardiovascular complications.
Area of Science:
- Cardiovascular Medicine
- Wound Healing Research
- Interventional Cardiology
Background:
- Keloid and hypertrophic scars represent abnormal wound healing.
- These scars share characteristics with restenosis after coronary stenting.
Purpose of the Study:
- To investigate the association between proliferative scars and coronary stent restenosis.
Main Methods:
- 80 patients who underwent coronary stenting post-sternotomy were analyzed.
- Patients were grouped based on the presence or absence of proliferative scars.
- The primary endpoint was angiographic restenosis incidence.
Main Results:
- 29% of patients had proliferative scars; groups were comparable at baseline.
- Restenosis was significantly more common in patients with proliferative scars (p = .04).
- Proliferative scar (OR 4.2, p = .02) independently predicted in-stent restenosis.
Conclusions:
- Patients with proliferative scars exhibit an increased risk of in-stent restenosis.
- This finding suggests a potential link between scar formation and cardiovascular outcomes.
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