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Does hyperbaric oxygen administration decrease side effect and improve quality of life after pelvic radiation?
Suyanto Sidik1, Daldiyono Hardjodisastro, Rianto Setiabudy
1Department of Internal Medicine, Hyperbaric Medicine, dr. Mintohardjo Navy Hospital, Jakarta, Indonesia.
Acta Medica Indonesiana
|November 30, 2007
Summary
Hyperbaric oxygen therapy (HBOT) significantly reduced side effects and improved quality of life for patients experiencing radiation proctitis. This study highlights HBOT as a beneficial treatment for pelvic radiation complications.
Area of Science:
- Oncology
- Radiotherapy
- Hyperbaric Medicine
Background:
- Pelvic radiation therapy can lead to significant side effects, including proctitis.
- Assessing the impact of hyperbaric oxygen therapy (HBOT) on these side effects and patient quality of life is crucial.
Purpose of the Study:
- To evaluate the influence of hyperbaric oxygen therapy (HBOT) on the incidence and severity of side effects.
- To assess the impact of HBOT on the quality of life in patients undergoing pelvic radiation.
Main Methods:
- An open, randomized, parallel, prospective study was conducted.
- Side effects were measured using the LENT SOMA scale, and quality of life was assessed using the Karnofsky score.
- Statistical analysis included the student t-test to compare group differences.
Main Results:
- HBOT significantly reduced both acute (ASE) and late (LSE) side effects compared to the control group (p<0.001 for ASE, p=0.008 for LSE).
- Quality of life significantly improved in the HBOT group immediately after intervention (p<0.001) and at 6 months (p=0.007).
- The HBOT group showed a greater improvement in quality of life scores compared to the control group.
Conclusions:
- Hyperbaric oxygen therapy (HBOT) is effective in decreasing acute and late side effects associated with pelvic radiation.
- HBOT demonstrably improves the quality of life for patients suffering from radiation-induced proctitis.
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