Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic inflammation after trauma.

Andreas Lenz1, Glen A Franklin, William G Cheadle

  • 1Veterans Affairs Medical Center, Louisville, USA.

Injury
|December 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does Chronic Immunosuppression Have a Negative Impact on Patients Who Require Emergency General Surgery?

Journal of the American College of Surgeons·2026
Same author

Necrotizing soft-tissue infections survival guide in adult patients: A position statement by the Global Alliance for Infections in Surgery.

The journal of trauma and acute care surgery·2025
Same author

The Evolving Role of Extracorporeal In Situ Perfusion Technology in Organ Donor Recovery with Donation After Circulatory Determination of Death Organ Donors.

Medicina (Kaunas, Lithuania)·2025
Same author

Nebulized Heparin and N-Acetylcysteine do Not Improve Outcomes of Intubated Burn Patients With Grade II or III Inhalation Injuries.

The American surgeon·2025
Same author

Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery.

World journal of emergency surgery : WJES·2024
Same author

Predictors of oliguria in post-traumatic acute kidney injury.

Surgery·2023
Same journal

Cumulative traumatic life events and increased risk for emergency department and inpatient utilization after physical injury hospitalization.

Injury·2026
Same journal

Advances in the management of chest wall injuries - Influence of new technical options.

Injury·2026
Same journal

Trauma nursing as frontline health diplomacy: A binational ATCN program for Palestinian and Israeli nurses during conflict.

Injury·2026
Same journal

Corrigendum to "Neutralizing the odds: Biomechanical protection by adiposity offsets physiological burden to explain the trauma.'obesity-paradox`" [Injury 57 (2) (2026) 112913].

Injury·2026
Same journal

Agreement between ChatGPT and emergency physicians in laceration management: A prospective study.

Injury·2026
Same journal

Lateral epicondylar fractures in the pediatric population: Presentation, management, and outcomes.

Injury·2026
See all related articles

Severe trauma triggers a complex immune response, including systemic inflammatory response syndrome (SIRS). This review details the immunological events, mediators, and pathways following trauma to understand its impact on mortality.

Area of Science:

  • Immunology
  • Trauma Research
  • Critical Care Medicine

Background:

  • Trauma is a leading cause of global mortality, with early deaths often resulting from initial injuries.
  • The immune system's response to trauma, known as systemic inflammatory response syndrome (SIRS), can lead to multi-organ dysfunction.
  • Subsequent insults ('second hits') can exacerbate inflammation, increasing morbidity and mortality.

Purpose of the Study:

  • To review the immunological events occurring after severe trauma.
  • To identify key mediators and pathways involved in the inflammatory response to injury.
  • To provide insights into the mechanisms underlying trauma-induced immune dysregulation.

Main Methods:

  • This is a review article, synthesizing existing research on trauma immunology.

Related Experiment Videos

  • It examines the roles of neuroendocrine and immune mediators, including hormones and cytokines.
  • Pathways of pro-inflammatory and anti-inflammatory responses are discussed.

    • Main Results:

    • Trauma activates multiple immune system components and the neuroendocrine system.
    • Mediators like hormones (ACTH, corticosteroids, catecholamines) and cytokines drive the inflammatory response.
    • The immune response shifts from pro-inflammatory to anti-inflammatory, potentially causing immune suppression and sepsis risk.

    Conclusions:

    • Understanding the immunological cascade after trauma is crucial for improving patient outcomes.
    • Key mediators and pathways offer potential targets for therapeutic interventions.
    • Further research into trauma-induced immune modulation is warranted to reduce mortality and morbidity.