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[Cardiotoxicity of n-methyl-glucamine antimoniate (Glucantime). A case report]
N Matoussi1, H B Ameur, S B Amor
1Service de pédiatrie-urgences-consultations, hôpital d'enfants de Tunis, 1007, rue Jabbari, Bab-Saâdoun, Tunisie. nadia.matoussi@rns.tn
Abstract:
The pentavalent antimonial meglumine (Glucantime) is the drug of choice in treatment of cutaneous leishmaniasis in Tunisia. It may create severe adverse effects. A ten year-old girl was treated by Glucantime for cutaneous leishmaniasis. On the eighth day of treatment, she developed palpitations and precordialgia. The ECG showed T wave inversion prolongation of corrected QT interval. Drug therapy was stopped. Within a few days, she recovered and her elctrocardiographic changes came back to normal. The cardio toxicity of Glucantime may be severe. Electrocardiographic changes are the primary signs. Long term ECG follow-up is necessary.
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