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Updated: Jul 9, 2026
07:19
Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array
Published on: September 7, 2018
Gl-NETs-uniform but also diverse
1GI Pathology, Northeast Region, Caris Diagnostics, Inc., 320 Needham Street, Suite #200, Newton, MA, USA. ydayal@carisdx.com
Endocrine Pathology
|December 7, 2007
Summary
Neuroendocrine tumors, initially called carcinoids, are a diverse group of neoplasms originating from the dispersed neuroendocrine cell system. Despite a century of study, their complexity and heterogeneity mean much remains to be discovered.
Area of Science:
- Oncology
- Endocrinology
- Pathology
Background:
- The term 'carcinoid' was introduced 100 years ago for indolent gastrointestinal tumors.
- Initially believed to be confined to the gut, these tumors are now known to arise in various organs.
- The concept evolved with the understanding of the dispersed neuroendocrine cell system, comprising over 20 distinct cell types.
Purpose of the Study:
- To review the historical context and evolving understanding of carcinoid tumors.
- To highlight the heterogeneity within this class of neoplasms.
- To emphasize the ongoing need for research despite significant advancements.
Main Methods:
- Historical review of carcinoid tumor research.
- Conceptual analysis of the neuroendocrine cell system.
- Discussion of tumor classification and heterogeneity.
Main Results:
- Carcinoid tumors are now understood as a family of neoplasms, not a single entity.
- These tumors exhibit significant heterogeneity in origin, function, and behavior.
- The dispersed neuroendocrine cell system provides a framework for understanding tumor diversity.
Conclusions:
- Our understanding of carcinoid tumors has progressed substantially over the past century.
- Despite progress, the complexity and heterogeneity of these tumors indicate that research is still in its early stages.
- Further investigation is crucial to fully elucidate the biology and clinical management of neuroendocrine neoplasms.
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