A novel oligosaccharide ester from Syringa pubescens.
Wei-Ping Yin1, Tian-Zeng Zhao, Hai-Yan Zhang
1Laboratory of Natural Products, Chemical Engineering and Pharmaceutics College, Henan University of Science & Technology, Luoyang, Henan, China. ywpq@163.com
Journal of Asian Natural Products Research
|December 7, 2007
Summary
A new compound, Pubescenside A, was isolated from Syringa pubescens flowers. This novel oligosaccharide ester demonstrated cytotoxic activity against the L2215 cell line.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Syringa pubescens (Lilac) is a plant with traditional medicinal uses.
- Investigating the chemical constituents of medicinal plants can lead to the discovery of novel bioactive compounds.
Purpose of the Study:
- To isolate and characterize novel compounds from Syringa pubescens flowers.
- To evaluate the cytotoxic potential of plant extracts.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic methods (NMR, MS).
- Cytotoxicity assay using the L2215 cell line.
Main Results:
- Pubescenside A, a novel oligosaccharide ester, was isolated and its structure determined.
- Five known compounds (D-mannitol, meso-inositol, hydrostytosol, glucose, sucrose) were also identified.
- The water extract of Syringa pubescens flowers and leaves exhibited cytotoxicity against L2215 cells with an IC(50) of 78 microg/ml.
Conclusions:
- Pubescenside A is a newly identified bioactive compound from Syringa pubescens.
- Syringa pubescens extracts possess cytotoxic properties, warranting further investigation for potential therapeutic applications.
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